【摘要】 目的研究不同剂量的阿托伐他汀对不稳定型心绞痛患者血清高敏C反应蛋白水平的影响。方法选取我院不稳定型心绞痛患者51例,随机分为小剂量组28例和大剂量组23例,分别给予阿托伐他汀10mg或40mg,每日1次。共用药30日,治疗前后分别测定患者血脂水平和血清高敏C反应蛋白水平。结果阿托伐他汀用药30日后,两组血脂水平和血清高敏C反应蛋白水平均明显降低,低剂量组从(17±6)μg/L降至(8.3±2.7)μg/L;高剂量组从(18±7)μg/L降至(8±3)μg/L。两组下降程度比较,差异有统计学意义。结论早期应用阿托伐他汀治疗不稳定型心绞痛,可减少斑块基质成分的降解和炎症反应,具有稳定斑块作用,使用大剂量阿托伐他汀的获益更多。更多还原

【Abstract】 Objectives To study effects of difference doses of atorvastatin on plasma high sensitivity C-reactive protein (hs-CRP) levels in patients with unstable angina. Methods A total of 51 patients with unstable angina were divided into two groups group 1 had 28 patients and was given low dose of atorvastatin (10 mg a day)for 30 days and the group 2 had 23 patients and took large dose of atorvastatin (40 mg a day) for 30 days also. The serum levels of TC, TG, HDL-C, LDL-C were detected before and after therapy. Results 30 days later, the levels of TC, TG, HDL-C, LDL-C, hs-CRP decreased significantly and the decreasing degree had statistical differences between two groups (P< 0.05). Conclusions Atorvastatin can decrease breakdown of matrix collagen,and inflammatory reaction in patients with acute coronary syndrome, especially in patients taken large doses.更多还原