【摘要】 目的探讨原发性高血压病患者血清脂联素浓度的变化及其与血压之间的关系。方法本研究选取原发性高血压病患者50例及健康人50例(正常对照组),常规测量血压、体质量、身高,计算体质量指数,检测血清脂联素、空腹血糖、血清胰岛素、总胆固醇、高密度脂蛋白胆固醇、甘油三酯等指标。再将50例高血压病患者分成两组,每组25例,分别用血管紧张素转换酶抑制剂西拉普利及血管紧张素Ⅱ受体拮抗剂替米沙坦治疗2周,治疗前后均检测上述指标。结果①原发性高血压病患者与健康对照者比较,血清脂联素水平下降犤(4.13±1.89)μg/mlvs(7.09±2.85)μg/ml,P<0.05犦,健康对照组脂联素浓度与体质量指数、总胆固醇呈负相关(r=-0.28,-0.26,P<0.05);②原发性高血压组血清脂联素浓度与收缩压、舒张压、甘油三酯呈显著负相关(r=-0.36、-0.32、-0.37,P<0.05),高血压组与健康对照组两组合并比较,脂联素浓度与BMI体质量指数、收缩压、舒张压呈显著负相关(r=-0.29、-0.28、-0.31,P<0.01);③高血压患者分别用西拉普利及替米沙坦治疗两周后,血压显著下降(P<0.05),血清脂联素浓度明显升高(P<0.05)。结论在原发性高血压病患者中,血清脂联素水平下降并与血压之间存在一定的相关性,与脂代谢紊乱亦相关。更多还原

【Abstract】 Objective To explore the serum concentrations of adiponectin in patients with essential hypertension,and the relations between adiponectin and blood pressure Methods Fifty cases with essential hypertension and fifty healthy control subjects were taken fasting blood samples for measurements of plasma glucose,plasma lipids,insulin and adiponectin Fifty patients with essential hypertention were treated with cilazapril or telmisartan for 2 weeks Serum adiponedtin concentration,BMI,BMP,SG,INS,TG,TC,HDLC were measured befored and after 2 weeks of treatment with cilazapril or telmisartan Results The concentrations of adiponectin in essential hypertensive case were significant lower than those in the control group Pearson relation analysis showed that adiponectin levels were negatively and significant correlated with BMI,TC in control group,with SBP,DBP,TG in essential hypertension group,and with BMI,SBP,DBP between two groups Treatment with cilazapril or telmisartan significantly decreased blood pressure and increased adiponectin concentrations Conclusions The adiponectin concentration is significant lower in patients with essential hypertension,and there is negative and significant correlation between adiponectin and blood pressure更多还原