【摘要】 目的　探讨血清催乳素 ( PRL)及卵巢癌相关抗原 ( CA1 2 5 )水平对不孕症患者中子宫内膜异位症 ( EMS)的早期诊断价值。方法　将 90例不孕患者中的患 EMS者设为 EMS组 ,以慢性盆腔炎为对照组 ,两组患者于腹腔镜或开腹手术前 1～ 3个月内的早卵泡期 ,采用时间分辨荧光免疫法检测PRL,放射免疫法检测 CA1 2 5水平。结果　 ( 1 )术后诊断 EMS患者 68例 ,慢性盆腔炎患者 2 2例。 ( 2 ) EMS组和对照组患者中 PRL≥ 1 8.1 ng/ml分别占 67.6%和 1 8.2 % ;CA1 2 5≥ 3 5 U/L分别占 2 7.9%和 0。 ( 3 ) ～ 期 EMS患者 :血清 PRL和 CA1 2 5的敏感性分别为 72 .9%和 5 .4% ,两者比较 ,差异有显著性( P<0 .0 1 ) ; ～ 期 EMS患者的 PRL和 CA1 2 5敏感性分别为 61 .3 %和 5 4.8% ,差异无显著性 ( P>0 .0 5 )。 ( 4 ) CA1 2 5≥3 5 U/L的 1 9例 EMS患者中 ,1 7例为 ～ 期 EMS患者。结论　 ( 1 )血清 PRL检测对不孕患者中 EMS的筛查有较高的参考价值。 ( 2 )测定血清 PRL水平对诊断 ～ 期 EMS的敏感性显著高于 CA1 2 5 ,而测定 CA1 2 5仅对 ～ 期 EMS的诊断特异性较高更多还原

【Abstract】 Objective To investigate the diagnostic value of serum prolactin(PRL) and CA125 level in infertil patients with endometriosis (EMS) .Methods Serum PRL by time-resolved fluorescence assay and CA125 by radioimmunoassay were detected in 90 infertil patients before laparoscopy or laparotomy. Results (1) 68 patients were diagnosed as EMS (EMS group), 22 patients were diagnosed as chronic pelvicinflammatory disease, pelvic tubercle and parovarian cyst(control group).In EMS and control groups, the rate of serum PRL≥18.1 ng/ml were 67.6% and 18.2% respectively; CA125≥35 U/L were 27.9% and 0 respectively.(2) In theⅠ～Ⅱstage EMS patients, the sensitivity of high level PRL was significantly higher than that of CA125(72.9% and 5.4%, respectively ) (P<0.01). But in the Ⅲ～Ⅳ stage EMS patients, there were no significant difference (61.3% and 54.8% respectively) (P>0.05). (3) In 19 patients whose serum CA125≥35 U/L,17 were diagnosed as Ⅲ～Ⅳ stage EMS. Conclusion (1)Serum PRL assay has high reference value in the infertil patients with EMS. (2) Serum PRL assay has a significant higher sensitivity than CA125 assay in the Ⅰ～Ⅱstage EMS, however, CA125 has a high specificity only in the Ⅲ～Ⅳstage EMS.更多还原