【摘要】 目的探讨特异性19SIgM-TPPA抗体检测方法在诊断新生儿先天潜伏梅毒中的价值,同时观察妊娠梅毒患者垂直传播发生情况,并探讨其意义。方法应用特异性19SIgM-TPPA抗体检测方法对177例孕妇梅毒所生的新生儿进行检测。结果177例受检新生儿中,TRUST阳性112例(63.3%),TPPA阳性156例(88.13%),19SIgM阳性27例(15.25%)。早期先天梅毒患儿TRUST≥母亲TRUST2个滴度以上9例、>母亲TRUST2个滴度以内7例、<母亲TRUST滴度5例;因母亲血清标本缺或血清量不足,无法作比较的6例。27例先天梅毒有临床表现的6例,无临床表现21例。结论特异性19SIgM-TPPA抗体检测方法可作为先天梅毒特别是无症状新生儿先天梅毒诊断的试验。产前梅毒筛查和治疗对预防梅毒垂直传播有重要意义。更多还原

【Abstract】 Objective:To explore the value of specific 19S-IgM-TPPA antibody for diagnoses of asymptomatic congenital syphilis and observe the situation of vertical transmission of syphilis pregnant women.Methods:177 infants whose mothers were syphilis patients were serologically screened for syphilis by 19S-IgM specific antibody test. Results:Among 177 infants,112(63.3%) were TRUST positive,156(88.13%) were TPPA positive and 27(15.25%)were 19S-IgM positive.Among the 27 infants with congenital syphilis, 6 had clinical symptoms and 21 had no. Conclusion:19S-IgM specific antibody test could be used for diagnoses of congenital syphilis, especially for cases without clinical symptoms.Antenatal routine screening and treatment for syphilis are important to prevent the vertical transmission of pregnant syphilis.更多还原