【摘要】 目的:比较低剂量吉西他滨6小时延时GP方案和常规GP方案的疗效、毒性和对肺功能的影响。方法:50例经病理或细胞学确诊的晚期非小细胞肺癌患者,随机分为延时GP方案和常规GP方案两组,其中30例患者化疗前后行肺功能检测,观察两方案疗效、毒性和对肺功能影响的差异。结果:延时组和常规组的近期有效率分别为32%和28%(P>0·05);中位疾病进展时间分别为7·4个月和7·5个月(P>0·05);1年生存率为32%和28%(P>0·05)。延时组Ⅲ-Ⅳ度的白细胞和血小板毒性均低于常规组(分别为20%vs48%,12%vs40%,P均<0·05);对肺功能的影响,延时组的FEV1/VC的升高率和TLCO的下降率亦均低于常规组(P<0·05)。结论:低剂量吉西他滨延时GP方案和常规GP方案,近期及远期疗效无统计学差异,但有更低的Ⅲ-Ⅳ度白细胞和血小板毒性;吉西他滨延时GP方案对肺功能的影响小于常规GP方案。更多还原

【Abstract】 Objective:1. To evaluate and compare the response, toxicity and lung function in advanced non-small-cell lung cancer patients treated by different GP regimen。Methods:1.50 patients with advanced NSCLC were randomly divided into two groups, which accepted gemcitabine 6h prolonged infusion GP regimen（25 case） or thirty-minute infusion GP regimen（25 case） respectively. 2. lung function of 30 patients were detected before and after chemotherapy. Results:1.The response and toxicity of two group: The response rate of 6-h prolonged infusion group was 32%, and the response rate of thirty-minute infusion group was 28% （P>0.05） . ②Median time to progressive disease were 7.4 months and 7.5 months in 6h prolonged group and in thirty-minute group （P>0.05 ）; 1-year survival rate were 32% and 28%, respectively （P>0.05）.③ Hematologic toxicity: grade 3 and 4 neutropenia occured more frequently in thirty-minute infusion group（48%） compared with 6h prolonged group（20%） （P<0.05）; grade 3 and 4 thrombocytopenia occured more frequently in thirty-minute infusion group （40%） compared with 6h prolonged group（12%） （P<0.05）. 2. The effect on lung function: The rate of increase of FEV₁/VC and the rate of decrease of TLCO in thirty-minute infusion group were higher than those of 6h prolonged infusion group （P<0.05）.Conclusion:Compared with thirty-minute infusion GP regimen, 6h prolonged infusion GP regimen has less grade 3 and 4 thrombocytopenia, neutropenia and lung toxicity.更多还原