【摘要】 目的观察紫杉醇联合氟尿嘧啶及顺铂(PFC)方案治疗国人晚期胃癌的临床疗效和毒副反应。方法晚期胃癌患者25例,给予紫杉醇(PTX)50mg/m2,静滴3小时,第1、8、15天给药;氟尿嘧啶(5-FU)750mg/m2,持续静脉输注24小时,第1～5天;顺铂(CDDP)20mg/m2,静脉滴注,第1～5天,28天为1周期。分别化疗2～6周期后按WHO标准评价疗效和毒副反应。结果全组25例均可评价疗效,获得CR2例,PR11例,SD7例,PD5例,近期客观有效率52.0%,中位TTP为6.5月。主要毒副反应为骨髓抑制、恶心呕吐和脱发。结论PFC方案治疗国人晚期胃癌疗效较高,毒副反应轻,多数患者耐受良好,值得推广应用。更多还原

【Abstract】 Objective:To evaluate the efficacy and toxicity of paclitaxel combined with 5-fluorouracil and cisplatin （PFC） regimen in patients with advanced gastric cancer.Methods:25 cases with advanced gastric cancer were enrolled.PTX 50mg/m2 iv 3hr d₁,5-FU 750mg/m2 iv 24hr d₁～d₅ and CDDP 20mg/m2 iv d₁～d₅;and repeated every 28 days.Results:All 25 cases were available for objective response.CR 2 cases,PR 11 cases,SD 7 cases,PD 5 cases.The overall response rates （ORR） and median TTP was 52.0% and 6.5 months respectively.The main toxicities were bone marrow suppression,nausea/vomiting and alopecia.Conclusion:PFC regimen is a high response regimen for advanced gastric cancer with well-tolerated toxicity,which can be practiced safely.更多还原