【摘要】 目的:探讨非小细胞肺癌(NSCLC)组织中血管浸润(BVI)和淋巴管浸润(LVI)所发生的不同程度的表达及其与NSCLC生物学行为的关系。方法:常规HE切片在光镜下从低倍镜到高倍镜全面观察切片,对116例NSCLC标本的BVI和LVI表达情况进行研究,分析其与临床病理因素的关系及内在联系。结果:NSCLC组BVI和LVI的阳性表达率分别为44.8%和31.9%,血管浸润和淋巴管浸润与NSCLC患者病理类型、肿瘤细胞分化程度、肿瘤大小以及患者年龄、性别无关;各术后TNM分期的BVI发生比较:Ⅰ期与Ⅲ期相比有显著性差异(P<0.05);各术后TNM分期的LVI发生比较:Ⅰ期∶Ⅱ期、Ⅰ期∶Ⅲ期LVI的发生相比有显著性差异(P<0.05);各N分期的BVI比较:0组∶1～3组、0组∶2组BVI的发生有显著性差异(P<0.05);各N分期的LVI比较:0组∶1～3组、0组∶2组LVI的发生有显著性差异(P<0.05)。结论:血管浸润、淋巴管浸润与淋巴结转移及术后TNM的高分期密切相关,对NSCLC临床病理学评价有重要意义。更多还原

【Abstract】 Objective:To study the clinical and pathological significance of the expression to blood vessel invasion (BVI) and lymphatic vessel invasion (LVI) in NSCLC tissues.Methods:Through studing the expression to blood vessel and lymphatic vessel invasion in NSCLC tissues of the 116 patients suffering from NSCLC by watching the HE insection of the NSCLC tissues, analyze the relation about the expression to BVI and LVI with the clinical and pathological factors. Results:The positive expression rates of BVI, LVI are 44.8% and 31.9% respectively. Expression of BVI and LVI have nothing to do with pathological types, size of the tumor, age, sex, and the differentiation of cancer cell of NSCLC, and have something to do with TNM stages, metastasis of lymph node, blood vessel invasion and lymphatic vessel invasion.Conclusion:BVI and LVI have important clinical and pathological significance in NSCLC.更多还原