【摘要】 目的:对于局部晚期不能行手术的胰腺癌的现行标准治疗方案为放疗联合5 -氟脲嘧啶(5- Fu),但如何给药 仍是一个值得探讨的问题。现将我院对不能切除的21例胰腺癌患者进行放疗联合化疗的治疗经验进行总结分析。方法:入 组患者全部为不能手术切除的局部晚期胰腺癌,采用4～6野适形放疗,总剂量为DT55～60Gy/27～30次,同期通过锁骨上 静脉营养管滴入5- Fu,250mg/m2/天,持续点滴6～8小时/天,5天/周,用药至放疗结束。结果:全部患者完成放疗,18例 (85.71%)完成化疗,7例(33.33%)PR,10例(47.61%)SD。主观指标评估,2例临床症状完全消失,17例(80.95%)主观症 状有所改善。中位肿瘤进展时间为6.9个月,中位生存时间9.2个月。结论:延长5 -Fu静滴时间+放疗,与5- Fu大剂量使用 +放疗局部控制率相似,远期控制率是否改善仍未有结果,但对改善临床主观症状有较好的作用,因此对晚期胰腺癌的姑息 性治疗是一种有效的方法。更多还原

【Abstract】 Objective:The standard treatment for unresectable pancreatic carcinoma is radiotherapy (RT) with 5-Fluorouracil (5-Fu), however, the optimal schedule for 5-Fu administration has not been established. The combination of 3DCRT and continuous infusion 5-Fu in 21 patients with locally unresectable pancreatic carcinoma was analyzed. Methods:Twenty-one patients with adenocarcinoma of the pancreas were enrolled in this clinical trial, RT was delivered using 3DCRT with dose of DT 55-60Gy in 27-30 fractions. 5-Fu was given through a central venous catherter at a dose of 250mg/m 2/day, 6-8 hours/day, 5d/wk, throughout the entire course of RT. Results:All patients completed the RT as planned and 18(85.71%) completed the full regimen of chemotherapy, seven patients (30%) had a partial response, and 10(47.61%) had stable disease. Subjective response defined as the disappearance of symptoms observed at diagnosis, was also evaluated, two patients had a complete, and 17 (80.95%) a partial remission of symptoms. The median time to progression was 6.9 months and the median survival time was 9.2 months.Conclusion:3DCRT and continuous infusion 5-Fluororacil was comparative with conventional RT and bolus 5-Fu in local effect. The effect to distant metastatic disease remains an open. However, the relieve of symptoms achieved by our study may be regarded as positive results.更多还原