【摘要】 目的:探索长期氧疗对慢性阻塞性肺疾病(COPD)血凝状态、内皮功能和肾功能的影响。方法:56例COPD患者,随机分成两组:(1)治疗组:30例,男性19例,女性11例,平均年龄(72.5±10.1)岁;(2)对照组:26例,男性14例,女性12例,平均年龄(73.9±9.5)岁。治疗组在出院后开始吸入申威8L压缩氧,吸入氧浓度(FIO2)29%,每日12h计1年。治疗前后常规检查肺功能(FEV1)、动脉血气,肝、肾功能、血沉(ESR)、血凝及血粘状态指标[D-二聚体、纤维蛋白原(FN)、血浆及全血粘滞度(高切、低切)、内皮素-1(ET-1)、血β2-微球蛋白]。结果:治疗组治疗后PaO2及SaO2增高(P<0.01),PCV、D-二聚体、血浆及全血粘度(高切和低切)均明显下降(P<(0.01);同时内皮功能也得到改善,ET-1下降。血肌酐降低(P<0.05);血β2-微球蛋白下降。对照组各指标均无变化(P>0.05)。两组治疗前后肝功能及尿素氮无显著差异(P>0.05)。结论:长期氧疗对改善COPD高凝状态、内皮功能和肾功能具有较好的疗效。更多还原

【Abstract】 Objective: To study the effects of long-term oxygen therapy(LTOT) on the blood coagulation condition and endotheliocyte function in patients with chronic obstructive pulmonary disease(COPD) . Methods: 56 cases were randomly divided into two groups. Therapy group: 30 cases and Control group: 26 cases. A 8L oxygen produced by shen-wei Co. Ltd of Shanghai, were taken by the therapy group everyday about 12 hours for 1 year. Pulmonary function (FEV1) .artery blood gas analysis, coagulation condition, ET-1 and Sβ2-MG were measured in all cases at beginning and after 1 year. Results: After treatment, PCV, D-D ,blood coagulation condition,ET-1 Sβ2-MG were obviously decreased(P<0. 01). With the improvement of above parameters, PaO2 and Sat. O2 % were increased (P<0. 01). There was no significant changes in control group. Conclusion: COPD patients benefit from LTOT after 1 year. Blood coagulation condition, endotheliocyte function and renal function in patients with chronic obstructive pulmonary disease is improved.更多还原