【摘要】 目的探讨慢性乙型病毒性肝炎血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)和Ⅳ型胶原(Ⅳ-C)在肝纤维化诊断中的应用价值。方法采用放射免疫分析法(RIA)检测150例慢性乙型病毒性肝炎患者血清HA、LN、PCⅢ和Ⅳ-C水平,并与肝组织活检纤维化程度进行相关性分析。结果各组慢性乙型病毒性肝炎患者血清HA、LN、PCⅢ和Ⅳ-C水平均高于正常对照组(P<0.05),与肝纤维化活动水平及程度呈密切正相关(P<0.01)。结论血清HA、LN、PCⅢ和Ⅳ-C水平能较好地反映乙型病毒性肝炎的慢性化程度和肝纤维化的活动水平及程度,联合检测可明显提高肝纤维化诊断的准确性和可靠性。更多还原

【Abstract】 Objective To investigate the changes of serum levels of collagen type Ⅳ(Ⅳ-C),procollagen type Ⅲ(PCⅢ),hyaluronic acid(HA)and laminin(LN)and their relationship with hepatic fibrosis in patients of chronic hepatitis B.Methods Serum levels of Ⅳ-C,PCⅢ,HA and LN were measured with radioimmunossay(RIA)in 150patients of chronic hepatitis B of various types.Degree of hepatic fibrosis was ascertained with their liver biopsy and correlationship with the corresponding levels of these 4 serum markers was studied.Results The levels of Ⅳ-C,PCⅢ,HA and LN in serum of patients with chronic hepatitis B of various types were higher than those of the control group.Serum levels of those markers were positively correlated with the degree of pathological changes of hepatic diesease and the activity of hepatic fibrosis.Conclusion Serum levels of these markers could reflect the degree of hepatic fibrosis and severity of liver damage.Combined determination of those markers is a sensitive and reliable diagnostic method in diagnosing hepatic fibrosis.更多还原