【摘要】 目的　总结应用侧脑室外引流联合尿激酶灌注治疗高血压基底节区出血破入脑室的经验 ,并与单纯侧脑室外引流的疗效进行对比。方法　对 5 9例高血压基底节区出血破入脑室患者中 3 2例行侧脑室外引流加尿激酶灌注 (A组 ) ,2 7例单纯采用脑室外引流 (B组 )。结果　A组重残6例 ,死亡 4例 ,持续引流时间 (7± 3 .1)d ;B组重残 5例 ,死亡 10例 ,持续引流时间 (12± 4.2 )d。两组死亡率和持续引流时间比较差异有显著性 (分别 P <0 .0 5和 <0 .0 1) ,生存质量方面两组重残构成比差异无显著性 (P >0 .0 5 )。结论　脑室外引流联合尿激酶灌注较单纯行脑室外引流虽不能明显改善存活患者神经功能 ,但可明显缩短引流时间 ,降低死亡率。更多还原

【Abstract】 Objective To summarize the treatment experience of lateral external ventricular drain (LEVD) in combination with infusion of urokinase and compare therapeutic effects with solely EVD.Methods The clinical data of 59 patients with intraventricular hemorrhage (IVH) caused by hypertensive intracranial hemorrhage (HICH) in basal ganglia region were analyzed retrospectively.The EVD in combination with infusion of urokinase was performed on 32 cases (group A).The solely EVD was done for 27 cases (group B).Results In group A,6 cases were severely disabled and 4 cases died.In group B,5 cases were severely disabled and 10 cases died.The mean time of continuous drainage were (7±3.1) days and (12±4.2) days respectively in group A and group B.The mean time of continuous drainage and mortality were significantly lower in group A than in group B (P<0.01 and P<0.05 respectively),but the proportion of the severely disabled had no significant difference between the two groups (P>0.05).Conclusion LEVD in combination with infusion of urokinase can significantly reduce mortality as compared with the solely EVD,although it cann’t improve neurologic outcome for the survivors.更多还原