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下呼吸道分离大肠埃希菌和肺炎克雷伯菌产超广谱β-内酰胺酶的危险因素分析

Risk factors of extended-spectrumβ-lactamase-producing clinical Isolates of escherichia coli and klebsiella pneumoniae from lower respiratory tract samples

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【作者】 穆雪鵾陈升汶卢月梅张阮章王沙燕

【Author】 MU Xuekun,CHEN Shengwen,LU Yuemei,et al.The Second Affiliated Hospital of the Medical College of Jinan University,Shenzhen 518020,China

【机构】 暨南大学医学院附属第二医院深圳市人民医院呼吸内科暨南大学医学院附属第二医院深圳市人民医院呼吸内科 518020深圳518020深圳

【摘要】 目的 探讨下呼吸道分离大肠埃希菌和肺炎克雷伯菌产生超广谱β 内酰胺酶(ES BLs)的危险因素。方法 收集本院83例下呼吸道标本分离出产ESBLs大肠埃希菌和肺炎克雷伯 菌的病例,同时选取44例ESBLs阴性菌病例为对照,进行单因素卡方检验和多因素非条件Logistic 回归分析。结果 下呼吸道分离菌ESBLs阳性率为65.35%;氧亚胺β 内酰胺类抗生素应用3天 以上、留置胃管和雾化吸入是产ESBLs的独立危险因素。结论 下呼吸道分离菌产ESBLs的情况 较严重,为多因素所致,主要为应用氧亚胺β 内酰胺类抗生素、留置胃管和雾化吸入等。

【Abstract】 Objective To explore the risk factors of ESBLs- producing clinical isolates of Escherichia coli and Klebsiella pneumoniae from lower respiratory tract samples.Methods Eighty-three cases of positive-ESBLs isolates from lower respiratory tract samples and 44 control cases of negative- ESBLs isolates were studied by Chi-square test and non-conditional Logistic regression analysis .Results To 65.35%of strains were considered ESBLs producers.The independent risk factors were using oxyiminoβ-lactam antibiotics over three days, indwelling nasogastric tube and aerosol inhalation.Conclusions The prevalence of ESBLs was high in clinical isolates of Escherichia coli and Klebsiella pneumoniae from lower respiratory tract samples.ESBLs-producing strain acquisition could attribute to multiple factors,mainly to using oxyiminoβ-lactam antibiotics,indwelling nasogastric tube and aerosol inhalation.

  • 【文献出处】 临床内科杂志 ,Journal of Clinical Internal Medicine , 编辑部邮箱 ,2005年02期
  • 【分类号】R56
  • 【被引频次】12
  • 【下载频次】40
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