【摘要】 目的:探讨西酞普兰治疗抑郁症的疗效和安全性。方法:将60例抑郁症患者随机分为西酞普兰组和马普替林组,治疗6周。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效,采用副反应量表(TESS)评定不良反应。结果:西酞普兰组显效率为83.3%,马普替林组显效率为76.7%,两组差异无显著性。HAMA减分率西酞普兰组明显多于马普替林组,西酞普兰组不良反应较少而轻微。结论:西酞普兰治疗抑郁症见效快,疗效肯定,不良反应轻,依从性好。更多还原

【Abstract】 Objective:To explore the efficacy and safety of citalopram in the treatment of patients with depression. Method:60 patients with depression were randomly assigned to citalopram group and maprotiline group for six weeks.Hamilton depressive scale(HAMD)、Hamilton anxiety scale(HAMA) and treatment emergent symptom scale(TESS) were used to assess the clinical efficacy and side effects. Results:The significant improvement rate of citalopram was 83.3% and that of maprotiline was 76.7%.There was no significant difference between the two groups.The score of HAMA was reduced more in citalopram group than in maprotiline group.The adverse reactions of citalopram were lower and lighter than that of maprotiline. Conclusion:Citalopram is an effective antidepressant with fewer side effects and takes effect rapidly.更多还原