【摘要】 目的:比较文拉法辛缓释剂(XR)与速释剂(IR)治疗抑郁症的疗效及不良反应。方法:对门诊及住院抑郁症患者60例随机分为两组,分别给予文拉法辛缓释剂或速释剂治疗12周。治疗前后给予汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效,副反应量表(TESS)评定不良反应。结果:缓释剂组显效率为86.6%,速释剂组显效率为83.3%。治疗后HAMD和HAMA评分均有显著减少。结论:与速释剂相比,缓释剂能有效的缓解抑郁、焦虑症状,且有较好的耐受性和依从性。更多还原

【Abstract】 Objective:To study the efficacy and side effects of venlafaxine extended release (XR) and venlafaxine immediate release (IR) in the treatment of depression. Method:Sixty depressed inpatients and outpatients were randomly divided into XR group or IR group for 12 weeks. Before and after treatment,all participants were examined with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) to assess the efficacy. The side effects were assessed by treatment emergent symptoms scale (TESS). Results:The improvement rate of XR and IR was 86.6% and 83.3% respectively.The scores of HAMD and HAMA decreased significantly after treatment in both groups. Conclusion:Compared with IR,XR not only improves the symptoms of depression and anxiety, but also has good tolerance and compliance.更多还原