【摘要】 探讨酒精性肝病患者IL - 6的活性改变与酒精性肝病肝纤维化的临床意义。测定了12 0例酒精性肝病患者和30例健康成年人(对照组)的IL - 6、HA、LN、PC -Ⅲ、Ⅳ-C。酒精性肝病患者,血清IL - 6明显高于对照组,有显著性差异(P <0 .0 5～0. 0 1)。酒精性肝病患者血清中HA、LN、PC -Ⅲ、Ⅳ-C的改变明显高于对照组(P <0. 0 1～0 .0 0 1)。IL - 6的活性改变与酒精性肝病的肝纤维化呈正相关性。更多还原

【Abstract】 To study the relationship be tween the change of interleukin-6 (IL-6) activity and the level of hepatic fibro sis in alcoholic liver disease (ALD).Among the 120 patients with ALD,the level o f interleukin-6 (IL-6)?hyaluronic acid (HA)?laminin (LN),type Ⅲ procollagen ( PC-Ⅲ) and type Ⅳ collagen (Ⅳ-C) in serum is monitored.The same items are moni tored in the control group with 30 healthy people.The in acase of IL-6 in ALD gr oup (P<0.05～0.001).The changes of HLIV?PC-Ⅲ and Ⅳ is marked nigher than the control group (P<0.001～0.0001).The changes of IL-6 activity is Posilive correlaled with the level of hepatic fibrosis in ALD.更多还原