【摘要】 目的探讨鼻咽癌多层螺旋CT灌注成像的临床应用技术。资料与方法22例鼻咽镜活检病理证实的鼻咽癌行多层螺旋CT灌注扫描,经肘静脉注射对比剂,多层螺旋CT对选定的鼻咽层面进行定层连续扫描30次,将4×30帧图像输入functionCT软件内,根据动脉动态增强-时间曲线和各组织强化值计算各层面内每一像素的灌注指标,并计算各指标与同层面正常肌肉的比值,以此来评价鼻咽癌和邻近组织的灌注状态。结果鼻咽癌组织血流量(BF)、强化峰值(PEI)、峰值到达时间(TTP)及血容量(BV)分别为(51.7±10.9)ml.100g-1.min-1、(35.4±5.2)HU、(14.5±1.7)s、(853.6±245.3)ml/100g,肿瘤组织和邻近正常肌肉灌注比值分别为7.0±1.8、4.1±1.4、0.6±0.1、6.9±3.9。结论正确的检查技术是灌注成像的重要保证,多层螺旋CT灌注成像可以显示鼻咽癌微循环灌注特征。更多还原

【Abstract】 Objective To discuss the technique of MSCT (Multi-slice CT) perfusion for nasophargeal carcinoma.Materials and Methods 22 patients of NPC proved pathology were underwent with MSCT perfusion, a continuous scan in same position were done with 4×5mm sections every 1.5 second for a duration of 45 seconds. The perfusion data of tumor and uninvolved lateralpterygoid muscle were recorded to calculate density-time curve and perfusion indexes using function CT software.Results The mean value of blood flow (BF), peak enhancement index (PEI), time to peak (TTP) and blood volume (BV) were 51.7±(10.9) ml/100g/min, 35.4±5.2 HU, 14.5±1.7s, 853.6±245.3 ml/100g, respectively. The rates of tumor and muscle were 7.0±1.8, 4.1±1.4, 0.6±0.1, 6.9±3.9, respectively. Conclusion The correct technique is guarantee for CT perfusion, the MSCT perfusion data can reflect the character of micro-vessel of nasophargeal carcinoma.更多还原