【摘要】 目的观察氧氟沙星联合丁胺卡那霉素在治疗耐多药肺结核治疗中的作用。方法将耐多药肺结核患者71例随机分为2组:治疗组(38例)采用卡那霉素联合利福平、结核清及吡嗪酰胺、乙胺丁醇,疗程18个月。结果患者完成化疗疗程时;治疗组痰菌阴转率89.5%,优于对照组54.5%,(P<0.01);治疗组病灶吸收率94.7%,优于对照组57.5%,治疗组空洞闭合率71.9%,也优于对照组35.3%,(P<0.05)。结论氧氟沙星联合丁胺卡那霉素治疗耐多药肺结核痰阴转高,病变吸收好,药物不良反应低,值得在临床上推广应用。更多还原

【Abstract】 Objective To observe the treatment effect of the ofloxacin and amikacin for MDR-TB case. Methods 71 MDR-TB patients were randomly divided into two groups: 38 cases in the observation group (treated with Ofloxacin and amikacin, RFP, Heqing, PZA, EB), 33 cases in the control group (treated with kanamycin, RFP, Heqing, PZA, EB). The duration of treatment was 18 months. Results The patients completed their treatment. The suptum smear negative conversion rate was 89.5% and 54.5% in the observation group and the control group respectively (P<0.01). The absorption of disease rate was 94.7% and 57.5% in the observation group and the control group respectively. The closed hollow rat was 71.9% and 35.3% in the observation group and the control group respectively. The rate in the observation group was significantly higher than that of the control group (P<0.05). Conclusion The ofloxacin and amikacin for MDR-TB was helpful to the suptum smear negative conversion and the absorption of the athology and lower side reaction. The regimen deserves to be popularized in the practice.更多还原