【摘要】 目的:探讨CD34在人鼻息肉组织中的表达及微血管密度(MVD)的临床意义。方法:采用免疫组织化学E livision P lus二步法,检测30例正常下鼻甲(对照组)和60例鼻息肉(鼻息肉组)组织中CD34蛋白的表达情况,对CD34阳性血管进行MVD计数,并了解微血管的分布情况。结果:在鼻息肉组织中CD34阳性表达较广泛,在正常下鼻甲组织中CD34呈散在的弱阳性表达。鼻息肉组MVD明显高于对照组(P<0.01),并且在鼻息肉组中Ⅱ型3期、Ⅲ型中的MVD较Ⅱ型1期显著升高(P<0.01)。结论:CD34的表达及微血管的增生与鼻息肉的发生、发展有关,对其检测有助于判断鼻息肉的发展趋势,为新的治疗方案的选择提供依据。更多还原

【Abstract】 Objective:To study the clinicopathologic significance of microvessel density(MVD) and the expression of CD34 in human nasal polyps.Method:Using Elivision Plus immunohistochenistry method.Thirty cases of normal inferior turbinate,60 cases of nasal polyps were stain with CD34.Result:MVD of CD34 marker showed higer in the group of nasal polyps than in the group of normal inferior turbinate(P<0.01).MVD in nasal polyps type Ⅱphase 3 and type Ⅲ was higer than that in the nasal polyps type Ⅱ phase1(P<0.01).Conclusion:MVD iss closely related with the formation edema and development of nasal polyps.Angiogenesis may play an important role in the development of nasal polyps.更多还原