【摘要】 目的:探讨炎性递质白三烯和组胺在变应性鼻炎发病机制中的作用,比较白三烯受体拮抗剂和抗组胺药治疗变应性鼻炎的疗效及其机制。方法:将符合入选标准的40例变应性鼻炎患者随机分为两组,分别给予孟鲁司特钠和氯雷他定治疗2周。治疗前、后分别检测患者血清特异性IgE、外周血及鼻腔分泌物中嗜酸粒细胞(EOS),并记录用药后医生和患者对疾病整体状况的评价。结果:治疗后两组患者血清特异性IgE、外周血及鼻腔分泌物中EOS计数均明显下降,与治疗前比较差异有统计学意义(均P<0.05);治疗后两组患者血清特异性IgE、外周血及鼻腔分泌物中EOS计数差异无统计学意义(均P>0.05)。结论:孟鲁司特钠和氯雷他定治疗变应性鼻炎效果相近;组胺和白三烯在病理生理学上均是引起变应性鼻炎的重要炎症递质,两者均是通过影响EOS聚集、活化和减少特异性IgE的形成而发挥作用;白三烯受体拮抗剂是治疗变应性鼻炎的一种新的有效药物。更多还原

【Abstract】 Objective:To study the roles of leukotriene and histamin in the pathogenesis of allergic rhinitis and to compare the efficacy between leukotriene receptor antagonist and antihistamine by mensurating specific IgE in serum and eosinophil in peripheral blood and nose secretion of patients with allergic rhinitis respectively.Method:The patients were randomly divided into two groups and administrated montelukast sodium and loratadine respectively for two weeks. The specific IgE in serum and eosinophil in peripheral blood and nose secretion smear of patients were detected and then the state was evaluated by patients themselves and doctors.Result:After treatment the level of specific IgE in serum and eosinophil count in peripheral blood and nose secretion smear of patients were significantly lower than that before treatment( P <0.05);There were no significant differences in the change of the level of specific IgE in serum and eosinophil count in peripheral blood and nose secretion smear between two groups after treatment( P >0.05).Conclusion:Treating patients with allergic rhinitis with montelukast sodium and loratadine were of similar effect. Histamin and leukotriene are both important inflammatory factors in the pathogenesis of allergic rhinitis and both play roles by affecting eosinophil accumulation and activation and by decreasing the formation of specific IgE. Leukotriene receptor antagonist is a new drug to treat allergic rhinitis.更多还原