【摘要】 目的:观察高血压所致慢性充血性心力衰竭(CHF)患者血清sF as浓度的变化并探讨其临床意义。方法:选取高血压所致慢性充血性心力衰竭患者22例,单纯高血压患者19例,正常对照组21例。采用EL ISA法测定血清sF as浓度。结果:①与正常对照组相比,高血压CHF组血清sF as水平显著升高(P<0.01),高血压无CHF组和对照组之间血清sF as的水平变化无统计学意义(P>0.05)。②sF as水平随心功能不全的加重而明显升高,心功能Ⅳ级组患者高于心功能Ⅱ、Ⅲ级组患者(P<0.05)。结论:由高血压所致慢性充血性心力衰竭患者血清凋亡相关因子sF as水平明显升高,细胞凋亡在此类心衰的发病机制中起了重要作用。更多还原

【Abstract】 Objective: To investigate the serum soluble Fas(sFas) level in patients with chronic congestive heart failure caused by hypertension and its clinical significance.Methods: Our study included 22 patients with chronic congestive heart failure caused by hypertension and 19 patients with simple hypertension;and 21 normal control subjects.The serum sFas level was measured by enzyme linked immunosorbent assay.Results: The serum sFas level was significantly higher in the patients with heart failure than those in the normal subjects and in the patients with simple hypertension(P<0.01).The serum sFas level in the patients with heart failure rised significantly with cardia insufficiency.The serum sFas level in the patients with grade Ⅳ chronic congestive heart failure were higher than those in the patients with grades Ⅱ and Ⅲ(P<0.05).Conclusion: The serum sFas level elevates in the patients with chronic congestive heart failure caused by hypertension,which may play an important role in the pathogenesis of chronic congestive heart failure.更多还原