【摘要】 目的:检测侵袭性牙周炎(AgP)龈沟液中白细胞介素(IL-8)的总量和浓度并探讨其与牙周临床指标的关系。方法:采用常规滤纸条法收集侵袭性牙周炎实验组患牙(T1)和健康牙(T2)各位点及正常对照组(C)各位点的龈沟液(GCF)样本,用ELISA法检测各样本中IL-8的总量和浓度。结果:3组受检牙龈沟液中IL-8的总量和浓度不同。侵袭性牙周炎患牙组GCF中IL-8总量高于健康牙位组(P<0.05)及正常对照组;而3组中IL-8浓度差异也有显著性,侵袭性牙周炎患牙组GCF中IL-8的浓度高于健康牙位组(P<0.05)和正常对照组;虽然GCF中IL-8浓度与牙周探诊深度(PD)、牙龈出血指数(BOP)、附着丧失(AL)无相关关系;但IL-8总量与以上牙周临床指标相关。结论:在侵袭性牙周炎患者龈沟液中IL-8是参与牙周炎症反应的重要调节因子。更多还原

【Abstract】 Objective: To detect the amount and concentration of interleukin-8 in the gingival crevicular fluid(GCF) from aggressive periodontitis(AgP) and to evaluate the relationships between aggressive periodontitis and clinic periodontal parameters.Methods: Following careful sampling of GCF with standardized filter strips in healthy control prosition sites and periodontitis position sites from AgP and healthy subjects,the levels of interleukin-8 were detected by ELISA technique.Results: The Interleukin-8 amount of GCF among three groups was significantly different.The Interleukin-8 amount of GCF in aggressive periodontitis(AgP) inflamed groups was significantly higher than those of healthy groups from aggressive periodontitis(AgP)(P<0.05)and healthy control groups;The concentration among them were also significant different.The Interleukin-8 concentration of GCF in aggressive periodontitis(AgP) inflamed groups was significantly higher than those of healthy groups from aggressive periodontitis(AgP)(P<0.05)and healthy control groups.There were no correlations between IL-8 concentration and bleeding on probing(BOP),probing depth(PD) and attachment loss(AL),but there had significantly positive correlations between IL-8 amounts and bleeding on probing(BOP)? probing depth(PD) ?attachment loss(AL).Conclusions: These results suggest that IL-8 may play an important role in pathogenesis of aggressive periodontitis.更多还原