【摘要】 目的:探讨细胞免疫与复发性阿弗它溃疡(recurrent aphthous u lcer,RAU)发病机制的关系及茶多酚(teapolyphenols,TP)对RAU的免疫调节作用。方法:用免疫方法建立SD大鼠RAU动物模型,将RAU大鼠随机分成阴性对照组、溃疡糊剂组和3个TP治疗组。用流式细胞仪检测成模前后及用药前后各组大鼠外周血T淋巴细胞亚群CD4+、CD8+细胞数量及比值。结果:实验大鼠溃疡模型成模后外周血CD4+及CD4+/CD8+较成模前显著降低(P<0.01),CD8+改变无统计学意义(P>0.05)。茶多酚各治疗组外周血CD4+、CD4+/CD8+回升,与阴性对照组有显著性差异(P<0.05),茶多酚各治疗组间比较没有显著性差异(P>0.05)。结论:RAU的发生与细胞免疫功能抑制有关,TP对大鼠RAU具有免疫调节作用,其免疫调节作用与给药方式无关。更多还原

【Abstract】 Objective: To observe the relationship between cellular immune and the pathogenesis of recurrent aphthous ulcer （RAU） and to evaluate the immune regulation of tea polyphenols（TP）on RAU. Methods: RAU models were established by injecting antigens into SD rats. Five groups, including control group, ulcer cataplasm group and three TP therapeutic groups, were divided randomly. The changes of CD₄⁺ and CD₈⁺ values in blood were measured by flow cytometry （FCM）. Results: Compared with normal group, the values of CD₄⁺ and CD₄⁺/CD₈⁺ showed significantly lower level in RAU rats （P<0.01）, while CD₈⁺ not（P>0.05）. After TP treatment, the values of CD₄⁺ and CD₄⁺/CD₈⁺ increased significantly （P<0.05）. It did not show any significant difference among three TP therapeutic groups（P>0.05）. Conclusion: The inhibition of cellular immune function may contribute to RAU incidence; TP had the immune regulation on experimental RAU rats, which wasn’t related to the way of administration in this experiment.更多还原