【摘要】 目的:观察库拉索芦荟对4-NQO诱导的大鼠口腔粘膜鳞癌发生的影响.方法:51只Wistar大鼠,随机分为5组,除对照组(9只,不处理)和丙二醇组(9只,仅涂丙二醇)外,肿瘤组(9只)和高低剂量预防组(各12只)均用0.5%4-NQO涂擦腭粘膜至12周.预防组动物同时灌喂高或低剂量芦荟12周.20周时所有动物同时处死,切取腭粘膜进行病理学评价和免疫组化PCNA检测.结果:肿瘤组癌变率为88.9%.高低剂量预防组癌变率分别为16.7%和25%.统计分析表明,高低剂量预防组癌变率明显低于肿瘤组(P<0.01),高低剂量预防组间无差异(P>0.05);PCNA阳性指数高低剂量预防组明显低于肿瘤组(P<0.05).结论:库拉索芦荟对实验性口腔粘膜鳞癌的发生具有一定的预防作用.更多还原

【Abstract】 Objective:The present study was undertaken to investigate the inhibitory effect of Aloe vera(chinensis) on 4-nitroquinoline 1-oxide(4-NQO)-induced oral carcinogenesis in Wistar rats.Methods:51 Wistar rats(6～7 weeks) were randomly divided into 5 groups after breeding for 1 week routinely.The 0.5% 4-NQO in propylene glycol was applied in all groups to treat their palate except an untreated control group,and propylene glycol alone in treated group for 12 weeks(3 times /week).The rats in preventive group were also fed A.Vera(chinensis) in high dosage(1.8?g/kg/d) or low dosage(0.3?g/kg/d) for 12 weeks,then switched to the basal diets for 8 weeks.The rats were necropsied at the 20th week.The incidences of palate neoplasms and cell proliferation activity estimated by PCNA label index were compared among groups.Results:The incidences of palate neoplasms in4-NQO alone was 88.9%.The frequency of palatal carcinoma in preventive group feeding A.Vera(chinensis) at high or low dosage was significantly reduced: In high dosage 16.7%(P<0.01) or low dosage 25%(P<0.01).Dietary administration of the aloe significantly decreased the PCNA label index of rat palatal mucosa,compared with those given 4-NQO alone(P<0.05).Conclusion:Aloe at the 2 different doses has the chemopreventive effect on oral mucosa carcinogenesis.更多还原