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釉质基质蛋白诱导延迟再植牙牙周愈合的研究

The study of enamel matrix proteins (EMPs) on periodontal healin after delayed replantation of incisors in Beagle dogs

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【作者】 高旭; 张苹; 谭建国; 冯海兰;

【Author】 GAO Xu, ZHANG Ping , TANJian- guo, FENG Hai- lan. ( Department ofProsthodontics, School ofStomatology, Peking University, Beijing 100081,China)

【机构】 北京大学口腔医学院修复科; 北京大学口腔医学院修复科 博士生北京100081(现在山东大学口腔医学院修复科工作); 副主任医师北京100081; 副主任副主任医师副教授北京100081; 主任主任医师教授北京100081;

【摘要】 目的:研究应用釉基质蛋白对延迟再植比格犬恒切牙牙周再生的影响。方法:选取3只比格犬的15颗干燥60min的切牙随机分为两组,实验组10颗牙根涂釉基质蛋白;对照组5颗牙根不涂釉基质蛋白,进行再植。8周后处死犬,每隔500!m切取5"m厚的横断切片作组织学观察。结果:与对照组相比,实验组牙再植后能显著地增加牙周膜性愈合的数量(P<0.001),并减少替代性吸收(P<0.001)。结论:釉基质蛋白能对延迟再植牙的牙周愈合有促进作用。

【Abstract】 Objective: To evaluate the effect of enamel matrix proteims ( EMPs) on periodontal healing after delayed replantation of permanent incisors in Beagle dogs. Methods: A total of 15 incisors of 3 Beagle dogs were selected for replantation after 60min dry-time. Experimental group consisted of 10 roots that were coated with EMPs, the control group consisted of 5 roots that were replanted without EMPs. After 8 weeks, the dogs were killed and the roots were prepared for histological evaluation. About 5#m thick cross-sections of the roots and surrounding tissue taken every 500$m were evaluated for healing. Results: The roots with EMPs showed significant increase in periodontal healing compared to roots without EMPs treatment ( P<0.001) and significant decrease in replacement resorption (P<0.001). Conclusion: The results suggested that EMPs enhances periodontal healing of delayed replantation.

  • 【文献出处】 口腔颌面修复学杂志 ,Chinese Journal of Prosthodontics , 编辑部邮箱 ,2005年03期
  • 【分类号】R782.12
  • 【被引频次】4
  • 【下载频次】168
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