【摘要】 目的评价阿莫西林-双氯西林对常见感染临床分离菌的体外抗菌作用。方法收集临床分离菌按CLSI/NCCLS推荐的琼脂对倍稀释法测定阿莫西林-双氯西林的最低抑菌浓度(MIC),并与相关抗菌药物进行比较。结果收集临床分离菌共513株,其中需氧革兰阳性菌248株,需氧革兰阴性菌265株。阿莫西林-双氯西林对受试的需氧革兰阳性球菌,包括肺炎链球菌、化脓性链球菌等链球菌属、甲氧西林敏感葡萄球菌、粪肠球菌具有高度抗菌活性,大多与阿莫西林-克拉维酸相仿,亦优于其他受试药,该药对卡他莫拉菌、流感嗜血杆菌抗菌作用强,其中对流感嗜血杆菌的产酶株作用略差;对伤寒沙门菌具有良好抗菌作用,对大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌和志贺菌的抗菌作用较差。结论阿莫西林-双氯西林对社区获得的上、下呼吸道感染和单纯性皮肤软组织感染的常见病原菌具有良好抗菌作用,对伤寒沙门菌作用亦强,提示该药为治疗上述感染的适宜选用药物之一。更多还原

【Abstract】 ObjectiveTo evaluate the in vitro antimicrobial activity of amoxicillin-dicloxacillin(AMO-DIC) against clinical strains isolated from common infections.MethodsClinical isolates were collected.Antimicrobial susceptibility testing was done by agar dilution method.The results were assessed according to the National Commmittee for Clinical Laboratory Standards(CLSI/NCCLS), and compared with selected antimicrobial agents.ResultsAntimicrobial susceptibility of 513 strains of clinical isolates was determined,including 248 strains of aerobic gram positive cocci and 265 strains of aerobic gram negative bacilli.AMO-DIC had excellent antibacterial activity against the aerobic gram positive cocci tested,including S.pneumoniae,S.pyogenes,methicillin-sensitive Staphylococci and E.faecalis.AMO-DIC also had good antibacterial activity against M.catarrhalis and H.influenzae,But it showed slightly poorer activity for β-lactamase-producing H.influenzae,E.coli,K.pneumoniae,P.mirabilis and Shigella spp.were not sensitive to AMO-DIC,but most strains of S.typhi were sensitive to AMO-DIC.ConclusionsAMO-DIC exhibits good activity against the common pathogens causing upper respiratory tract infections,lower respiratory tract infections,and uncomplicated skin and soft tissue infections.It is also highly active against S.typhi.These results indicate that AMO-DIC is one of the appropriate drugs indicated for the treatment of above-mentioned infections.更多还原