【摘要】 目的　观察脑心通胶囊对大鼠局灶性脑缺血再灌注后脑损伤的保护作用。方法　以大鼠局灶性脑缺血再灌注模型为研究对象,应用神经功能行为学评分、TTC染色技术和ELISA观察脑心通胶囊对大鼠局灶性脑缺血再灌注后脑损伤的保护作用及对脑组织内白细胞介素 1β(IL- 1β)、白细胞介素 6(IL- 6)和肿瘤坏死因子 α(TNF- α)含量的影响。结果　脑心通胶囊0. 24 、0 .48 g/kg能降低模型大鼠神经功能行为学评分(P<0 .05),减少模型大鼠脑组织脑梗死范围(P<0 .01),降低脑组织中IL -1β、IL 6和TNF α的含量(P<0 05,P<0. 01)。结论　脑心通胶囊对大鼠局灶性脑缺血再灌注后脑损伤有保护作用,其作用机制与降低模型大鼠脑组织中IL -1β、IL -6及TNF -α的含量有关。更多还原

【Abstract】 Objective To observe the protective effects of Naoxintong Capsules (NCs) against the cerebral damage in the rat experienced focal cerebral ischemia/reperfusion and on the cerebral infarct size and the cerebral levels of IL-1β,IL-6 and TNF-α. Methods The rat model of focal cerebral ischemia/reperfusion was used to observe the effects of NCs against the cerebral damage in the rat experienced focal cerebral ischemia/reperfusion and on the cerebral infarct size and the cerebral levels of IL-1β, IL-6 and TNF-α by using neuronal function behavior scoring, TTC staining, and ELISA. Results NCs doses of 0.24 g/kg and 0.48 g/kg could decrease the neuronal function behavior score (P<0.05), reduce the cerebral infarct size (P<0.01), and decrease the cerebral levels of IL-1β, IL-6 and TNF-α (P<0.05, P<0.01) in the rats in the model group. Conclusion The results suggest that NCs possess protective effects against the cerebral damage caused by focal cerebral ischemia/reperfusion, the mechanism of which is related to its decreasing the cerebral levels of IL-1β, IL-6 and TNF-α.更多还原