【摘要】 目的探讨细胞粘附因子(CD44v)在胃癌细胞中的表达及临床意义。方法采用EnVisionTM免疫组化法检测65例胃癌细胞和胃切缘黏膜细胞中的CD44v表达率,并进行临床病理分析。结果胃癌组的CD44v表达率明显高于胃切缘黏膜组(P<0.01),中、低分化组胃癌细胞的CD44v表达率高于高分化组(P<0.05),伴有淋巴结转移的胃癌细胞CD44v表达率明显高于无淋巴结转移的胃癌细胞(P<0.05),Ⅲ～Ⅳ期组的胃癌细胞的CD44v表达率高于Ⅰ～Ⅱ期胃癌细胞(P<0.05)。结论检测胃癌的CD44v表达水平,可为临床提供判断胃癌患者临床分期和预后的参考指标。更多还原

【Abstract】 Objective To investigate the clinical significance of CD_44vlevel in tumor cells of patients with stomach carcinoma.Methods Sixty-five stomach carcinoma cases were examined to observe the CD_44v expression in tumor cells and normal mucosal cells by using Envision TM immunohis-tochemical method These data were clinicopathologically analyzed and compared with statistical methods.Results The CD_44v expression rate in tumors cells of stomach carcinoma was obviously higher than that in normal mucosal cells（P<0.001）.The CD_44vexpression rate in moderate-low differentiation tumor cells was higher than that in high differentiation tumor cells（P<0.05）.The CD_44vexpression rate in tumor cells with metastasis of lymph node was higher than that in tumor cell without metastasis of lymph node （P<0.05）.The CD_44v expression rate in tumor cells of patients with Ⅲ～IV stage was higher than that in tumor cells of stage Ⅰ～Ⅱ （P<0.05）.Conclusion The CD_44vlevel in tumor cells of stomach carcinoma is a useful index for clinical staging and prognosis.更多还原