【摘要】 目的通过测定抑郁症患者血小板五羟色胺(5-HT)浓度,探讨抑郁症治疗前后5-HT变化及其与临床特征的关系。方法用高效液相色谱法(HPLC)及电化学探测仪测定60例抑郁症患者治疗前后血小板5-HT浓度,并与30名正常者对照比较,同时作相关分析。结果治疗前后抑郁症患者血小板5-HT浓度均显著低于正常对照组(t=5.38,P<0.001;t=3.63,P<0.001);治疗前血小板5-HT浓度与HAMD因子1(焦虑/躯体化)有显著相关性(r=-0.88,P=0.001)。结论抑郁症患者血小板5-HT浓度明显降低,治疗前焦虑/躯体化症状与5-HT浓度呈负相关。更多还原

【Abstract】 Objective: To study the relationship between depression and blood palate 5-HT concentration . Methods: High performance liquid chromatography with electrochemical detection (HPLC-ECD) were used to determine the palate 5-Htconcentration in 30healthy controls and 60 patients with depression before and after treatment. Results:The palate 5-HT concentrations of the patients before and after treatment were significantly lower than that of the health controls( t =5.38, P <0.001; t =3.63, P <0.001).Palate 5-HTconcentration was negatively associated with scores of factor 1 (anxiety/ somatization )of HAMD before treatment( r =-0.88, P =0.001).Conclusion:Palate 5-HT concentration of patients with depression was significantly lower. Before treatment anxiety/somatic symptoms were associated with 5-HT concentration.更多还原