【摘要】 目的研究慢性抽动障碍与多巴胺D5受体基因多态性是否相关联。方法采用聚合酶链式反应(PCR)、限制性片段长度多态性(RFLPs)与琼脂糖电泳技术的方法,对176个符合CCMD-3诊断标准的慢性抽动障碍儿童与其亲生父母的多巴胺D5受体基因多态性分型,采用病例对照研究,数据统计采用单体型相对风险(GHRR和HHRR)与传递不平衡检验(TDT)方法进行分析。结果慢性抽动障碍与多巴胺D5受体基因多态性无显著关联。GHRR值为0.32～1.61;HHRR值为1.82;TDT值为2.25,其P值均大于0.05。结论慢性抽动障碍与多巴胺D5受体基因多态性无关联。更多还原

【Abstract】 Objective: To detect the genetic association between chronic tic disorder (CTD) and the polymorphism in the dopamine receptor D 5 gene. Methods: The genetype was detected with polymerase chain reaction ( PCR ) and restriction fragment length polymorphisms ( RFLPs ) technique. The data were analyzed with hyplotype relative risk ( GHRR and HHRR ) and transmission disequilibrium test ( TDT ) methods. Results: In the DSM-Ⅳ and CCMD-3 diagnosed CTD children ( n=176 ) and their parents, we found no significant association between the dopamine receptor D 5 gene and CTD ( GHRR: x 2=0.32~1.61, df = 1, P > 0.05; HHRR: x 2 = 1.82, df =1, P > 0.05 and TDT: x 2 =2.25, df = 1, P > 0.05 ). Conclusion: The results do not support that CTD is associated with the polymorphism of the dopamine receptor D 5 gene in Han population.更多还原