【摘要】 目的:了解白细胞介素-6基因启动子MbiⅠ多态性在中国广西不同民族中的分布。方法:应用聚合酶链反应-限制性片段长度多态性技术检测壮族和汉族人的白细胞介素-6基因启动子Mbi Ⅰ多态性,比较2组白细胞介素-6基因型和等位基因的分布频率。结果:在壮族人中CC基因型占56.22%、CG基因型占41.08%、GG基因型占2.70%;在汉族人中CC基因型占66.67%、CG基因型占32.32%、GG基因型占1.01%。两组白细胞介素-6基因型的分布频率差异有显著性。结论:壮族与汉族白细胞介素-6基因Mbi Ⅰ多态性分布频率差异有显著性。更多还原

【Abstract】 Objective: To detect the distribution of interleukin-6 gene promoter region Mbi Ⅰ polymorphism in the Chinese Zhuang and Han nationality in Guangxi province. Methods : Interleukin-6 gene promoter region Mbi Ⅰ polymorphism was detected by poly merase chain reaction-restriction fragment length polymorphism in Zhuang (n = 185) and Han (n=198). Results: The frequencies of CC, CG and GG genotypes were 56. 22%, 41. 08% and 2. 70% in the Zhuangs, and 66. 67%, 32. 32% and 1. 01% in the Han, respectively. A significant difference was seen in the distribution frequency of interleukin-6 genotype between the Zhuang and the Han (P<0. 05). Conclusion: There is significant difference of interleukin-6 gene promoter region Mbi I polymorphism between the Zhuang and the Han.更多还原