【摘要】 目的　探讨小鼠肾小体形态的发生规律。　方法　应用光镜、电镜技术并结合体视学方法和图像分析技术对生前和生后小鼠肾脏中各发育阶段的肾小体进行形态学观察和立体计量学的测量。　结果　可见肾小体发育的 4个阶段 ,胚龄 14d时 ,Ⅰ、Ⅱ期肾小体出现 ,生后 7d消失。胚龄 16d时 ,Ⅲ、Ⅳ期肾小体出现 ,其体积从胚龄 16d到生后 4 0d增大约 70倍 ,数目从胚龄 16d到生后 7d增加约 2 0倍 ,生后 7d后基本恒定。　结论　小鼠肾小体于胚龄 14d发生 ,生后 7d前增殖明显 ,生后 7d后不再增殖 ,肾小体的发育以单个体积迅速增大为特点。更多还原

【Abstract】 Objective To investigate the morphological origin of mouse renal corpuscles. Methods Light and electron microscope combined with stereological methods and image analysis technology were used to observe and measure renal corpuscles at different developmental stages of embryonic and postnatal mice. Results Four developmental stages of renal corpuscles could be observed. Renal corpuscles of stage Ⅰand Ⅱ first appeared at embryonic day 14(E14) and disappeared at postnatal day 7(P7). Renal corpuscles of stage Ⅲ and Ⅳ emerged at E16, their total volume increased almost 70-fold from E16 to P40, their number ranged approximately 20-fold from E16 to P7, and didn’t change any more after P7.Conclusion Renal corpuscles of mice form at E14; proliferation is prominent before P7; from P7 to P40, the developing characteristic of renal corpuscles is marked by volume growth of average unit.更多还原