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大蒜提取液抑制人结肠癌细胞SW480和SW620的增殖和扩散

Restraint of Proliferation and Spreading of Human Colorectal Cancer Cells SW480 and SW620 by Aqueous Extract of Garlic

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【作者】 李招发徐雪松孙立文申兴桂庄妍赵志壮李青山付学奇

【Author】 LI Zhao-fa~1,XU Xue-song~2,SUN Li-wen~1,SHEN Xing-gui~1,ZHUANG Yan~1,ZHAO Zhi-zhuang~1,LI Qing-shan~1,FU Xue-qi~1(1.Edmond H Fischer Laboratory of Signal Transduction,College of Life Science,Jilin University,Changchun 130021,China;2.China-Japan Union Hospital,Jilin University,Changchun 130031,China)

【机构】 吉林大学生命科学学院Edmond H Fischer细胞信号传导实验室吉林大学中日联谊医院吉林大学生命科学学院Edmond H Fischer细胞信号传导实验室 长春130021长春130031长春130021长春130021

【摘要】 研究了天然大蒜提取液对人结肠癌细胞SW 480和SW 620的扩散、粘附和增殖的影响.结果表明:将SW 480和SW 620加入1μL/孔大蒜提取液的DMEM中,癌细胞扩散率降低了40%;培养96 h,增殖率分别降低8.6倍和10.8倍.表明大蒜提取液能抑制人结肠癌细胞SW 480和SW 620的增殖和扩散.

【Abstract】 The effects of aqueous extract from garlic on spreading,adhesion and proliferation of human colorectal cancer cells SW480 and SW620 were tested.The results show the spreading ratios of both SW480 and SW620 cells are reduced 40%,proliferation ratios of SW480 and SW620 which were cultured for 96 h in DMEM containing 1 μL/well aqueous extract from garlic are reduced 8.6 and 10.8 times than that of control.The experiment indicateted that aqueous extract from garlic restrained proliferation and spreading of human colorectal cancer cells SW480 and SW620.

【基金】 国家自然科学基金(批准号:30470391);吉林大学创新基金(批准号:450011022055)
  • 【文献出处】 吉林大学学报(理学版) ,Journal of Jilin University (Science Edition) , 编辑部邮箱 ,2005年05期
  • 【分类号】R285;
  • 【被引频次】6
  • 【下载频次】256
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