【摘要】 目的比较氟伏沙明和氯丙咪嗪治疗强迫症的疗效和不良反应。方法用CCMD-3作为诊断标准,用Yale-Brown强迫量表和TESS量表评定临床疗效和不良反应,对58例强迫症患者进行随机双盲的8周治疗。结果氟伏沙明有效率为70.2%,与氯丙咪嗪60.7%相近,两者无显著差异。氟伏沙明不良反应发生率36.7%,明显少于氯丙咪嗪75.0%。两者有明显差异。结论氟伏沙明治疗强迫症,疗效与氯丙咪嗪相当,不良反应较轻,耐受性好。更多还原

【Abstract】 Objective To compare the efficacy and adverse effects of fluvoxamine and chlormipramine in treating patients with obsession. Methods According to CCMD-Ⅲ, 58 patients with obsession were randomly divided into fluvoxamine group and chlormipramine. The duration of treatment was 8 weeks. Yale-Brown scale and TESS were used to evaluate the efficacy and adverse effects respectively. Results The effective rates of fluvoxamine group and chlormipramine were 70.2% and 60.7%, which showed no significant difference between the two groups. The occurred rate of adverse effects of fluvoxamine decreased significantly than that of chlormipramine (36.7%, 75.0% respectively).Conclusions Fluvoxamine has more efficacy than chlormipramine, but has less adverse effects in treatment of obsession.更多还原