【摘要】 目的　评价脑力隆在偏头痛治疗中对脑血流速度及血液流变学的影响及与治疗效果关系。方法　将83例偏头痛患者,分为脑力隆治疗组42 例,尼莫地平治疗对照组41 例。治疗前后观察TCD、血液流变学的改变并对头痛情况进行评价。结果　两组治疗后MCA、PCA、ICA血流速度均较前有显著下降(P <0.01),治疗组的MCA、PCA、ICA血流速度较对照组改善更为明显(P <0.01或P <0.05);治疗组总有效率89.8%,高于对照组总有效率72.4%,两组疗效具有显著性差异(P < 0.05)。结论　脑力隆在钙离子通道拮抗剂治疗偏头痛中疗效更显著,这可能与其对血液粘度的明显改善有关。更多还原

【Abstract】 Objective To evaluate the effect for flow velocity of blood and hemorheology in migraine patients with Naolilong and the relationship between the improvement and the therapy.Methods 83 clinical-confirmed migraine patients were divided into two groups, 42 patients with Naolilong therapy, another 41 patients with Nimodipine for controls. After the course of treatment we evaluated the headache and measured the changes in flow velocity using TCD(transcranial Doppler ultrasonography.) Results The flow velocity of MCA(middle cerebral artery), PCA(anterior cerebral artery) and ICA(internal carotid artery) show significantly lower than before treatment in all 83 patients (P<0.01), the group with Naolilong shows more significant lower compared with the controls (P<0.01 or P<0.05), the symptoms are improved significantly in patients with Naolilong by 89.8% compared with the controls by 72.4% (P<0.05). Conclusions These findings show that using Naolilong as a new calcium antagonist in migraine patients can significantly increase the effects since its possible association with the obvious improvement of blood viscosity.更多还原