【摘要】 目的探讨血管内皮生长因子(VEGF)与胸外伤肺水肿的关系。方法将家兔分为受伤前和受伤后1、2、4、12、24、48、72h8组,用ELISA方法,观察家兔胸外伤后血浆VEGF的变化和肺组织的病理变化。结果家兔胸外伤后2h,部分肺组织轻度水肿,伤后24h肺组织明显水肿,伤后72h肺水肿减轻。血浆VEGF在胸外伤后均升高,以伤后24h、48h、72h与伤前比较差异有显著性(P<0.01),伤后24h、48h与伤后1h、2h比较,差异亦有显著性(P<0.01)。结论家兔胸外伤后血浆VEGF的变化与肺水肿的程度基本一致。更多还原

【Abstract】 Objective: To investigate the relationship between the vascular endothelial growth factor (VEGF) and pulmonary edema of chest trauma. Methods: Rabbits were divided into eight groups, included non-injury group and groups of 1 hour, 2 hours, 4 hours, 12 hours, 24 hours,48 hours, 72 hours after injury. With the method of ELISA, the plasma VEGF and the pathology of the lung of the rabbits were observed. Results: For the rabbits, the lung become edema partly at 2 hours after injury, remarkably at 24 hours after injury and relieved at 72 hours after injury. The VEGF are higher in the injury groups than that in the non-injury group, and only remarkably higher in the 24 hours, 48 hours and 72 hours groups (P<0. 01). Also the VEGF is remarkably higher in the 24 hours and 48 hours groups than that in the 1 hour and 2 hours groups (P<0. 01). Conclusion: The plasma VEGF accorded with the pulmonary edema in the rabbits of chest trauma.更多还原