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固本延衰方对亚急性衰老模型小鼠脾淋巴细胞增殖的影响
Influence of Guben Yanshuai Recipe on the Spleen Lymphocyte Proliferation of the Rat Model with Subacute Senility
【摘要】 目的探讨固本延衰方延缓亚急性衰老模型小鼠衰老的机制。方法将60只小鼠随机分为4组,除正常对照组外均皮下注射D-半乳糖造成衰老模型,并给予不同剂量的固本延衰方治疗,用MTT法测定脾淋巴细胞增殖水平。结果衰老模型组脾淋巴细胞增殖水平明显低于正常对照组(P<0.01),固本延衰方大小剂量组脾淋巴细胞增殖水平均高于衰老模型组(P<0.01),结论固本延衰方可提高衰老机体淋巴细胞增殖活性,从而调节免疫功能延缓衰老。
【Abstract】 Objective: To research the mechanism Of GubenYanshuai Fang(GBYSF) to postpone the senescence of the subacute aging model mice. Methods: 60 mices be divided into 4 groups and made aging model using D-glucose subcutaneous injection except the control group. After treating with different dosage GBYSF, We detect the spleen lymphocyte proliferation. Results:The level of spleen lymphocyte proliferation in model group is lower than that of control group(P< 0. 01),the level of spleen lymphocyte proliferation in maximum and minimum dosage of GBYSF group are higher than that of model group(P<0. 01). Conclusion: It implies that GBYSF could postpone aging from improving the level of spleen lymphocyte proliferation then regulating the body’s immune function.
【Key words】 GBYSF； D-glucose； Aging； Spleen lymphocyte proliferation；
- 【文献出处】 湖北中医学院学报 ,Journal of Hubei College of Traditional Chinese Medicine , 编辑部邮箱 ,2005年03期
- 【分类号】R285;
- 【下载频次】71