【摘要】 超氧化物歧化酶(Superoxide dismutase,SOD)是一类重要的具有抗氧化损伤功能的金属酶.利用生物信息学手段,分析了钝顶螺旋藻(Spirulina platensis)Fe-SOD的结构与进化,结合此蛋白的功能,揭示了两者的内在联系:在结构上,此蛋白的中间区域(26AA~160AA)结构紧凑,为酶的活性中心,两端区域离活性中心较远;在进化上,此蛋白两端区域较中间区域更倾向于发生突变.并且通过Fe-SOD,首次对以上三者间特殊关系的形成机制进行了猜想与假设.更多还原

【Abstract】 The Superoxide dismutase (SOD) is a kind of important metal enzyme for protecting organism from toxic oxidation. In this paper, the structure and evolvement of Spirulina platensis Fe-SOD were predicted by the method of bioinformatics. Related to its function, it was showed that: about its structure, the midst of the protein sequence (26AA~160AA) was tight and it was the active center of the enzyme, the ends were far from the active center; as to its evolvement, the ends of the protein sequence were more inclined to mutant. According to the Fe-SOD, a hypothesis about the mechanism of this relation was put forward for the first time.更多还原