【摘要】 目的探讨新斯的明拮抗维库溴铵的剂量与时机。方法60例患者随机分成3组(各20例),各组均连续输注维库溴铵,术毕前5min停止输注维库溴铵,周围神经刺激不能引起反应时A组先予静脉推注新斯的明0.015mg/kg+阿托品0.15mg,待T1恢复至10%时静脉推注新斯的明0.035mg/kg+阿托品0.25mg;B组即时静脉推注新斯的明0.035mg/kg+阿托品0.25mg;C组待T1自然恢复至10%时静脉推注新斯的明0.035mg/kg+阿托品0.25mg;记录从停止输注维库溴铵至T1恢复至90%、TOF恢复至70%和90%的时间;术毕15min时T1、TOF比值。结果A组T1恢复至90%、TOF恢复至70%和90%的时间较B、C组缩短(P<0.01,P<0.05);术毕15min时T1、TOF比值A组较B、C组高(P<0.01)。结论应用新斯的明的剂量与时机影响维库溴铵肌松作用的拮抗。更多还原

【Abstract】 Objective To evaluate the optimum dose and time of neostigmine against vecuronium-induced neuromuscular blockade.Methods Neostigmine was administrated while neuromuscular transmission was blocked and no activity of peripheral nerves could be induced by using a continuous infusion of vecuronium,60 patient were randomized into 3 groups,with 20 patient in each group.Group A received neostigmine 0.015mg/kg and atropine 0.15mg,in advance and when T₁ value recovered to 10%,neostigmine 0.035mg/kg and atropine 0.25mg,Group B received neostigmine 0.035mg/kg and atropine 0.25mg, when T₁ va lues had recovered to 10%.We recorded the time from the ceasion of vecuronium infusion to the recovery of T₁ to 90%.TOF to 70% and 90%,and T₁ value and TOF ratio at 15 minutes after operation.Results Recovery of T₁ to 90%,TOF to 70% and 90% in group A were faster than those in group B、C（P<0.01,P<0.05,respectively）,T₁ value and TOF ratio in group A at 15 minutes after operation were also higher than those in other two groups（P<0.01）.Conclusion Dose and time of neuromuscular administration can affect the anatgonism effect to vecuronium-induced neuromuscular blockade.更多还原