【摘要】 目的 :探讨糖尿病患者QT离散度 (QTd)改变及与糖尿病植物神经病变和室性心律失常间的关系。方法 :用同步 12导联心电图测定 6 9例糖尿病患者的QTd、最大QT间期 (QTmax)和经心率校正的QTmax (QTc max) ,同时用Holter监测其心率变异性 (HRV)和室性心律失常发生率 ,并与 6 1例非糖尿病人进行对比分析。结果 :①糖尿病组QTd较非糖尿病组显著增加 (P <0 0 1) ;②糖尿病组心率变异性指标中正常RR间期的标准差(SDNN)、每 5分钟正常间期标准差的平均值 (SDNN -index)较非糖尿病组显著降低 (P <0 0 5 )。糖尿病组QTd与每 5分钟正常RR间期平均值标准差 (SDANN)、SDNN -index存在明显相关性 (P <0 0 5 )。③糖尿病组QTd与室性心律失常存在着明显的正相关 ,而非糖尿病组QTd与室性心律失常的发生无明显相关性。结论 :糖尿病组QTd较非糖尿病组延长 ,且QTd与植物神经病变和室性心律失常相关 ,QTd可作为预测糖尿病患者发生恶性室性心律失常的有用指标。更多还原

【Abstract】 Objective:To investigate the relationship between the QT dispersion (QTd) and autonomic neuropathy and ventricular arrhythmias in diabetes.Methods:QTd,Maximun QT(QTmax) and heart rate-corrected QTmax were mearsured on standard 12-lead electrocardiogram(ECG)at baseline in 69 diabetic patients.Holter was used to detect heart rate variation(HRV) and incidence of ventricular arrhythmias,69 diabetics were compared with 61 nondiabeties.Results:①QTd was significantly higher in diabetics than nondiabeties(P<0.01);②HRV indices SDDN?SDDN-index were significantly lower in diabetics than nondiabetics(P<0.05),definite correlation of QTd with SDANN and SDNN-index in diabetics;③There was a significantly positive correlation between QTd and ventricular arrhythmias in diabetics,but definite correlation was not found between QTd and ventricular arrhythmias in nondiabetics.Conclusion:QTd was longer in diabetics than nondiabetics,there was correlation QTd with autonomic neuropathy and ventricular arrhythmias,QTd may be an useful predictor of severe ventricular arrhythmias in diabetics.更多还原