【摘要】 目的　了解临床分离的致感染大肠埃希菌的耐药性及产超广谱β-内酰胺酶 (ESBL s)情况 ,指导临床合理使用抗生素控制感染性疾病。方法　采用 Miroscan Walk Away4 0全自动细菌分析仪 ,对临床分离的 10 0株致感染大肠埃希菌进行细菌鉴定、抗生素敏感性测定和产 ESBL s判定。结果　所测抗生素大肠埃希菌耐药率在 5 0 %以上的占 14种 ,耐药率最高的为氨苄青霉素 ,亚胺硫霉素最为敏感 ,耐药菌株耐受抗生素种类从 1到 19种 ,多重耐药菌株占 93% ,产 ESBL s菌株为 4 9% ,产 ESBL s株对绝大部分抗生素的耐药率高于非产 ESBL s株。结论　致感染大肠埃希菌普遍耐药 ,尤其多重耐药广泛流行 ,临床医师须高度重视本医院和本地区大肠埃希菌的药物敏感模式与流行分布 ,合理使用各种抗生素以减缓细菌耐药对其的筛选压力 ,控制耐药菌株的流行更多还原

【Abstract】 Objective To analyze the antimicrobial resistance of clinical Escherichia coli and the situations of ESBLs-producing clinical isolates of Escherichia coli for guiding the rational use of antibiotics to control infections. Methods Identification, susceptibility tests of 20 antibiotics and ESBLs detection tests were performed using Microscan WalkAway40. Results The resistant rates to 14 antibiotics were higher than 50%. The clinical isolates of Escherichia coli were highly resistant to ampicillin, but were highly susceptible to imipenem. The number of antibiotics encountering resistance of clinical isolates of Escherichia coli ranged from 1 to 19; 93% of the isolates were multidrug-resistant; 49% of the isolates produced ESBLs. The resistant rates of ESBLs-producing isolates to 14 antibiotics were higher than those of non-ESBLs-producing isolates. Conclusion The antimicrobial resistance of clinical isolates of Escherichia coli, especially that of multidrug-resistant isolates, is highly prevalent. So doctors must pay great attention to the resistance pattern and the distribution of Escherichia coli in the hospitals and localities where they work. Rational use of antibiotics should be emphasized for reducing the pressure of screening to control the prevalence of antimicrobial resistance.更多还原