【摘要】 以金刚烷胺和1∶10(Ln∶W),1∶13(Ni或Mn∶V)系列多金属氧酸盐为原料,合成了化学式分别为K4(C10H18N)5CeW10O36·2H2O(APOM-5),K4(C10H18N)5PrW10O36·2H2O(APOM-6),K3(C10H18N)4NiV13O38·H2O(APOM-12)和K3(C10H18N)4MnV13O38·H2O(APOM-13)的四种新的多金属氧酸盐,并通过元素分析、IR光谱及1HNMR谱对其结构进行了表征.在狗肾(Madin-Darbycaninekidney,MDCK)细胞内,对合成化合物进行了抗流感病毒A和B的活性研究.发现APOM-13对流感病毒A,B两型均有明显的抑制活性,而APOM-12只在浓度较高时对流感病毒A,B两型有抑制活性,低浓度时,活性不明显.APOM-5,6对A型流感病毒有效,但对B型流感病毒抑制活性不明显.另外发现APOM-12和APOM-13对流感病毒感染MDCK细胞病变效应(CPE)具有明显抑制作用,且浓度越大抑制作用愈明显.更多还原

【Abstract】 Four novel polyoxometalates constructed from amantadine and a series of polyoxometalates [1∶10 (Ln∶W) and 1∶13 (Ni or Mn∶V)], which can be formulated as K4(C10H18N)5CeW10O36?2H2O (APOM-5), K4(C10H18N)5PrW10O36?2H2O (APOM-6), K3(C10H18N)4NiV13O38?H2O (APOM-12) and K3(C10H18N)4MnV13O38?H2O (APOM-13) respectively, have been synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy methods. The antivirus activity of the synthesized compounds was investigated on the inhibitory effect against both influenza types A and B in Madin-Darby canine kidney (MDCK). It indicates that APOM-13 had significant inhibitory activity against both A and B and APOM-12 had inhibitory activity against both A and B only in high concentration but it was not remarkable in low concentration. APOM-5 and APOM-6 have effectively activity against influenza A but not significantly to- wards B. In addition, it was found that APOM-12 and APOM-13 exhibited good inhibitory effect on MDCK cytopathogenic effect (CPE) that was infected with influenza virus and the inhibitory activity was more evi- dent in higher concentration.更多还原