【摘要】 通过4-芳基-5-(4-吡啶基)-1,2,4-三唑-3-硫醇(1)和2-三苯基甲基-5-(4′-溴甲基联苯-2-基)-四唑(5)反应,制得一系列新的S-烷基化产物(6),S-烷基化产物在酸性条件下脱保护,得到了14个未见文献报道的含1,2,4-三唑类联苯四唑(7a～7n)衍生物.结构经元素分析,IR,NMR及FAB-MS确认.对大肠杆菌、链球菌、枯草杆菌、金黄色葡萄球菌初步抑菌试验证明,多数化合物表现了较好的抑菌活性.更多还原

【Abstract】 S-Alkylation products were synthesized by the reaction of 4-aryl-5-(4-pridyl)-1,2,4-triazole-3- thiol (1) with 2-trityl-5-(4′-bromomethylbiphen-2-yl)tetrazole (5). An attempt to remove the trityl group of S-alkylation products 6 under acidic conditions gave fourteen new triazole ring containing biphenyl tetra- zoles 7a～7n in good yields. The structures of these compounds synthesized were confirmed by elemental analyses, IR, NMR and FAB-MS. Primary antibacterial test against E. coli, Streptococcus, B. subtilis and S. aureus showed that most of them had good antibacterial activities.更多还原