【摘要】 综述了天然双环核苷、抗病毒构效研究中的双环核苷和反义寡核苷酸领域中双环及三环核苷的合成研究进展,介绍了常规官能团转化法及近年来出现的自由基环合、1,3-偶极环加成和烯烃复分解等新方法。更多还原

【Abstract】 This paper reviewed the research in the synthesis of bicyclic nucleosides naturally occurring and in antiviral structure-activity research, as well as bi- and tri-cyclic nucleosides in antisense oligonucleotides. The method of functional group conversion and new methods of radical cyclization, 1,3-dipolar cycloaddition, ring-closing metathesis were involved.更多还原