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双环及三环核苷的合成
Synthesis of Bi- and Tri-cyclic Nucleosides
【摘要】 综述了天然双环核苷、抗病毒构效研究中的双环核苷和反义寡核苷酸领域中双环及三环核苷的合成研究进展,介绍了常规官能团转化法及近年来出现的自由基环合、1,3-偶极环加成和烯烃复分解等新方法。
【Abstract】 This paper reviewed the research in the synthesis of bicyclic nucleosides naturally occurring and in antiviral structure-activity research, as well as bi- and tri-cyclic nucleosides in antisense oligonucleotides. The method of functional group conversion and new methods of radical cyclization, 1,3-dipolar cycloaddition, ring-closing metathesis were involved.
【关键词】 双环核苷;
三环核苷;
自由基环合;
1,3-偶极环加成;
烯烃复分解;
【Key words】 Bicyclic nucleosides; Tricyclic nucleosides; Radical cyclization; 1; 3-Dipolar cycloaddition; Ring-closing metathesis;
【Key words】 Bicyclic nucleosides; Tricyclic nucleosides; Radical cyclization; 1; 3-Dipolar cycloaddition; Ring-closing metathesis;
【基金】 天津市自然科学基金资助项目(05YFJMJC09600)
- 【文献出处】 化学通报 ,Chemistry , 编辑部邮箱 ,2005年12期
- 【分类号】O629.2;
- 【下载频次】216