【摘要】 在三乙胺的作用下,将邻苯二甲酰亚胺基丙酰氯与含1 苯基 3 甲基5 氯苯氧基 4 吡唑基的席夫碱通过[2 +2 ]环加成反应生成8个单环β内酰胺类化合物。无论用旋光的还是外消旋的丙氨酸为原料制酰氯,反应后都得到反式构型的β内酰胺产物,这一点由1HNMR谱及1H 1HCOSY、NOESY、HMBC、HMQC二维核磁谱得到确证。目标化合物经元素分析、IR、1HNMR谱确证结构。更多还原

【Abstract】 The Schiff_base 1a～1h reacted with phthalimidopropionyl chloride in the presence of triethylamine to yield monocyclic β-lactams 2a～2h by [2+2] cycloaddition. The configuration of new monocyclic β-lactams are -trans whether phthalimidopropionyl chlorides are chiral or racemic. This was confirmed by 1H NMR、 1H- 1H COSY、NOESY、HMBC、HMQC spectroscopy. The structures of all new compounds were confirmed by elemental analysis、IR and 1H NMR spectral data.更多还原