【摘要】 目的豚鼠乳腺增生病模型方法的建立和病理组织形态学观察。方法采用给豚鼠已烯雌酚、黄体酮联合注射法所致乳腺增生病动物模型。测量乳头直径及高度,检测血清中雌二醇、黄体酮;对乳腺、子宫、卵巢组织作形态学观察与评价。结果与对照组比较,各实验组的乳头直径及高度显著性增加,乳腺组织切片可见典型的乳腺增生,血清中各激素的水平也有不同的变化;子宫、卵巢组织发生不同程度的增生与充血。结论采用已烯雌酚、黄体酮注射能成功复制豚鼠乳腺增生病动物模型。更多还原

【Abstract】 Objective To study the way of establishing the gninea pig model with mastopplasia and morphological observation of pathological tissue.Methods With injection of diethylstilbestrol and progesterone in all animals,the diameter and height of mammilla were measured,the level of estradiol and progesterone was tested and the tissues of breast,matria and ovary were observed morphologically.Results Compared with the control group,the diameter and height of mammitllas raised significantly and the cut-sections of breast tissue had typical hyperplasia on all animals.The level of hormone in serum also showed different changes.Hyperplasia and hyperemia existed in matrix and ovary.Conclusion The mammoplasia model in gninea pig can be duplicated with inection of estradiol progecterone are injected estradiol and progesterone the mastopathy gninea pig model.更多还原