【摘要】 目的:观察多潘立酮、奥美拉唑及盐酸氟西汀联合应用治疗功能性消化不良(FD)的临床疗效,探讨治疗FD的理想方案。方法:120例FD患者随机分为3组,每组40例。MOF组:采用多潘立酮+奥美拉唑+盐酸氟西汀治疗;MO组采用多潘立酮+奥美拉唑治疗;MF组采用多潘立酮+盐酸氟西汀治疗。疗程均为4周,治疗前及4周后对患者腹胀、上腹部不适、早饱、烧灼感、食欲不振、嗳气6个主要症状进行评分,计算疗效指数。结果:治疗前3组症状积分差异无显著性(P>0.05),治疗后3组症状积分均有明显降低,与治疗前比较有显著性差异(P<0.01),但MOF组积分较其它两组下降得更低,与其它两组治疗后比较有显著性差异(P<0.01);MOF组总有效率和显效率分别为87.5%和67.5%,MO组分别为67.5%和42.5%,MF组分别为62.5%和35.0%,MOF组的总有效率和显效率明显高于MO组(P<0.05)及MF组(P<0.01)。结论:三联疗法(多潘立酮、奥美拉唑及盐酸氟西汀)治疗FD疗效显著,是理想的治疗方案。更多还原

【Abstract】 Objective: To observe therapeutic effect of domperidone combined omeprazole and fluoxertine on functional dyspepsia (FD) and to investigate the better treatment plan for FD. Methods:120 cases of patients with FD were randomly divided into three groups (40 cases in each group).MOF group received all above three kinds of drugs. MO group received domperidone and omeprazole and MF group received domperidone and fluoxertine.The score of six present symptoms (abdominal distension, epigastric discomfort, early full, burning sensation, poor appetite, belching) was recorded before and four weeks after treatment, and index of therapeutic effect was calculated. Results: Symptom accumulated points had no difference in all three groups before treatment (P>0.05), but it decreased significantly after treatment(P<0.01), and those in MOF group decreased markedly compared with the others groups(P<0.01). Total effective rate and excellence rate were 87.5% and 67.5% in MOF group, 67.5 % and 42.5 % in in MO group,62.5 % and 35.0 % in MF group respectively. Total effective rate and excellence rate in MOF group were significant higher than those in MO group(P<0.05) and in MF group(P<0.01). Conclusion: Trigeminy therapy (domperidone combined omeprazole and fluoxertine) is a better plan in treatment of FD.更多还原