【摘要】 目的:了解静滴卷曲霉素临床治疗复治菌阳肺结核病人的不良反应发生情况。方法:选择经过静滴卷曲霉素治疗的复治肺结核病例,随访调查不良反应发生情况。结果:151例使用静滴卷曲霉素病人中出现不良反应者29例,不良反应发生率为19.2%。出现不良反应依次为低血钾、肾功能损害、低血钙、第Ⅷ颅神经损害,发生时间多在给药4周左右。结论:卷曲霉素引起的不良反应以低血钾、低血钙电解质紊乱及肾功能损害较为常见,及时补钾、补钙治疗可以纠正。对易出现第Ⅷ颅神经损害的儿童患者不宜首选卷曲霉素,对于老年及肾脏病史者慎用或减量使用。更多还原

【Abstract】 Objective: To evaluate the adverse drug reactions（ADRs） of Capreomycin（CPM） using to treat tuberculosis with positive sputum smear. Methods: The positive sputum tuberculosis were given the treating regimen（2CHRZE/6H₃R₃E₃） containing capreomycin,isoniazid,rifampin,pyrazinamide and ethambutol. To observe ADRs of CPM. Results: Total 151 cases treated by CPM,29 cases suffered from ADRs. The rate was 19.2%. There were total seven kinds of ADRs. These ADRs were hypokalemia,renal injury,hypocalcium,Ⅷ cranialnerve’s injury respectively. Most of them had been happened in the fourth week after CPM had been applied. Conclusion: The hypokalemia was the most common, and cured by kalium supplied with vein. The renal injury and Ⅷ cranialnerve’s injury were more serious. The physician should be cautious to use CPM for elder and infant tuberculosis.更多还原