【摘要】 目的:探讨窒息新生儿血清及脑脊液中促红细胞生成素(EPO)的变化及其与脑损伤的关系。方法:采用放射免疫法对63例足月窒息新生儿(窒息组)血清、脑脊液及20例正常足月新生儿(对照组)血清中EPO浓度作动态检测(生后24h内、第3d、第5d)。结果:窒息组血清EPO浓度较对照组有不同程度的增高,但合并重度缺氧缺血性脑病(HIE)组低于中度HIE组的测定值,生后5d内血清EPO动态变化不明显,脑脊液中EPO浓度与血液中浓度变化规律相似,血清及脑脊液中EPO浓度正相关。结论:窒息后脑脊液中促红细胞生成素水平增高,可能与自身神经保护作用有关。更多还原

【Abstract】 Aim: To investigate the change of erythropoietin (EPO) concentration in serum and cerebrospinal fluid (CSF) in neonatal asphyxia and study the relationship between brain injury and EPO concentration. Method: EPO concentration in CSF and serum was measured by radioimmunoassy in 63 full-term asphyxia infants, in 20 normal term neonates at postnatal day 1, 3, 5, respectively. Results: The EPO concentration in serum was higher in asphyxiated newborns than that of control infants. However, the level of EPO in severe hypoxia-ischemia encephalopathy (HIE) group was lower than that of moderate HIE group.The EPO concentration in serum had no significant change within 5 days after birth. The EPO concentration in CSF had a similar changing pattern with that in blood. There was a positive correlation of EPO concentration in serum and CSF.Conclusion: The concentration of EPO in CSF was increased after asphyxia, and may correlated with itself neuroprotection.更多还原