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神经干细胞移植入Alzheimer病模型鼠脑内的存活和分化
Survival and differentiation of the neural stem cells after transplantation into the brain of AD rat models
【摘要】 目的 研究神经干细胞移植治疗AD的可行性。方法 将从新生大鼠海马齿状回分离、培养的神经干细胞注入AD模型大鼠海马 ,4周后研究干细胞在体内存活和分化的情况。结果 神经干细胞在体内可以存活 ,部分可以分化 ,大部分分化为胶质细胞 ,小部分分化为神经元。结论 神经干细胞移植对AD有治疗作用。
【Abstract】 Objective To explore the feasibility of neural stem cells (NSCs) transplantation to treat Alzheimer’s disease. Methods NSCs ,from dentate gyrus of hippocampus of newborn rats and then cultured, were transplanted into the hippocampus of AD rat models . Four weeks later,the differentiation and survival of NSCs were checked. Results NSCs can survive in vivo and part can differentiate. The major differentiate into astrocyte and the minor differentiate into neuron. Conclusion Transplantation of NSCs can treat AD.
【关键词】 神经干细胞;
移植;
分化;
Alzheimer病;
【Key words】 Neural stem cell; Transplantation; Differentiation; Alzheimer’s disease;
【Key words】 Neural stem cell; Transplantation; Differentiation; Alzheimer’s disease;
- 【文献出处】 实用神经疾病杂志 ,Henan Journal of Practical Neurons Diseases , 编辑部邮箱 ,2005年02期
- 【分类号】R749.16
- 【被引频次】1
- 【下载频次】177