节点文献
位阻型硅烷化试剂在药物合成中的研究与应用
Application of Organosilan as a Protective Reagent in the Synthesis of Pharmaceuticals
【摘要】 综述了位阻型硅烷化试剂的特点、保护原理和应用。就其在保护含杂原子的有机官能 团方面讨论了对羟基、羧基、羰基及胺基等的保护和去保护条件及其在药物合成中的应用。并对位 阻型硅烷化试剂的发展趋势进行展望。
【Abstract】 The characteristics, protective principle and application of Sterically hindered silane blocking agents were reviewed. Organochlorosilane is widely used in the protection of organic functional groups involving hetero atoms, such as hydroxyl, carboxyl, carbonyl, amino group and so on .The conditions of protection and deprotection and the application development in the synthesis of pharmaceuticals are given in the article. Its trend of development is viewed in this article.
【关键词】 位阻型;
氯硅烷;
保护基团;
药物合成;
选择性;
【Key words】 Sterically hindered; Organochlorosilane; protective group; synthesis of pharmaceuticals; selective;
【Key words】 Sterically hindered; Organochlorosilane; protective group; synthesis of pharmaceuticals; selective;
【基金】 江西省自然科学基金资助项目(No 0520038)
- 【文献出处】 精细化工中间体 ,Fine Chemical Intermediates , 编辑部邮箱 ,2005年05期
- 【分类号】TQ463.1
- 【被引频次】7
- 【下载频次】363